TY - JOUR AU - Shirali, Akio AU - Huijsmans, Wilson Minter AU - Sottocornola, Matteo PY - 2018/12/21 Y2 - 2024/03/28 TI - Letter to the Editor: Genetic Editing of Secretory Pathway of Penicillium Chrysogenum After Observation of Increased Secretory Rates in an Increased Stress Environment (Microgravity), a Research Proposal by High School Students in Dubai JF - Fine Focus JA - finefocus VL - 4 IS - 2 SE - DO - 10.33043/FF.4.2.163-169 UR - https://openjournals.bsu.edu/finefocus/article/view/1547 SP - 163-169 AB - In this study, we aim to amplify the secretory pathway of Penicillium Chrysogenum within the ISS or similar simulated microgravity using the miniPCR and/or RTQ-PCR and then optimizing Penicillium Chrysogenum function using CRISPR cas-9 (Clustered Regularly Interspaced Short Palindromic Repeats), a new technology in the genetics which can help in gene alteration for better drug production. The secretory pathway of Penicillium Chrysogenum is controlled by genes pcbAB , pcbC and penDE ER -