Phage Therapy: Challenges and Opportunities

Authors

  • Immadi Siva Ratnakar Sri Sathya Sai Institute of Higher Learning

DOI:

https://doi.org/10.33043/FF.8.1.12-35

Keywords:

Bacteriophages, Antibiotic resistance, Phage, Phage therapy, Alternative treatments, Clinical trials, Immune, Food Safety

Abstract

The development of antibiotic resistance in bacteria is a growing concern. This situation demands a search for antibiotic alternatives. Bacteriophages—natural viral predators of bacteria—are viewed as a possible alternative to treat bacterial infections. Many clinical trials today have not found phages effective as therapeutics. Some of the major challenges regarding usage of bacteriophage as a therapeutic have been: horizontal evolution of bacteria, limited host range of bacteriophage, removal of endotoxins in preparations, the technical feasibility of isolation, mode of administration, rapid clearance and immune rejection.
These issues have been addressed in this review. Applications of genetic engineered phages and other remarkable non-human applications are also discussed.

Downloads

Download data is not yet available.

Downloads

Published

2022-07-18

How to Cite

Immadi Siva Ratnakar. (2022). Phage Therapy: Challenges and Opportunities. Fine Focus, 8(1), 12–35. https://doi.org/10.33043/FF.8.1.12-35

Issue

Vol. 8 No. 1 (2022)

Section

Articles

License

Copyright (c) 2022 Immadi Siva Ratnakar

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

By submitting to Fine Focus, the author(s) agree to the terms of the Author Agreement. Beginning in Fall 2018, all authors retain copyrights associated with their article contributions and agree to make such contributions available under a Creative Commons Attribution-NonCommercial 4.0 International license upon publication in Fine Focus. Copyrights to articles published prior to Fall 2018 have been transferred from the authors to Fine Focus.